Abstract

Genomics, transcriptomics, and proteomics research in pathogenic bacteria is related to and complementary to research into the human microbiome. The PAThosystems Resource Center (PATRIC, patricbrc.org), for example, aggregates a wide range of organism specific information on genomes, proteomes, metabolic pathways, diseases, and related literature. Using metagenomic abundance profiles, one can link metagenomes to their constituent organisms and perform analysis on a wide range of data related to those organisms. Important biological questions require both metagenomic and genome-specific data to be resolved. For example: are there potential reservoirs for antibiotic resistance in the human microbiome, to what extent is lateral transfer a factor in the genomics of the microbiome organisms, and which bacteria are communal in some host sites while pathogenic in other sites? The first step to answering questions such as these is to integrate detailed genomic and metagenomic data. This poster describes functionality under development in the PATRIC resource to link broad sets of organism specific data to publicly available data in PATRIC and MG-RAST metagenomic analysis results.

International Human Microbiome Congress